I think the best combo is big man and a 1 or 2 guard, or a good 3.
With a 2 guard
This would include running through the big man and having open shots for the other players, that would also mean you need a 1 and 3 that can shoot. This works if you have a big man that can pass, but with most of the teams they will go to the big man but not run through him.
eg from teams: Shaq-Kobe, Lebron-Boozer, Carter-Bosh, Finley-Dirk (meh), Brand-Maggette (need to play D), Tmac-Gooden (lol), Wade-Odom, Crawford-Curry-Chandler (they've had their chance,
not Chandler this year but Curry and Crawford etc
The inside outside game is always the best to play on, and then you get a good shooting, good defensive pg that can pass relatively well.
eg: Andre Miller with a 3 point shot or Antonio Daniels, Snow with a three point shot, Alvin Williams better 3, Tinsley etc.
Then at the 3 you'd have a player that has a good mix of D and O, and can shoot from the outside (well it would be a bonus). The player also can't be a guy that needs the ball to be effective.
eg: Tayshaun, James Posey, Battier, Stephen Jackson, Peterson, Hayes, Josh Howard, Bowen, Kedrick Brown (if he can be a starter), Caron Butler (might take away shots), Johnatan Bender etc.
The other inside position wouldn't matter if you have a Center or Power Forward as your main man. With a center, you'd need a shot blocking 4, that can rebound and put up about 9-14 ppg. If your man was a power forward, the same thing, a shot blocking center that can pull down boards and give you about 9-14 ppg.
eg: Ben, Camby, Donyell Marshall, Chandler, Dampier, Magloire, Nene (with blocks), Rasho, Kandi, Kaman, Keon Clark, Joe Smith, Stromile, Ethan Thomas, Gadzuric, Skinner, Okur etc.
Lastly, the bench, I think a good thing to have is a low post scorer, or a big man that can play D, rebound and block.
If you went scorer: Corliss Williamson, Maurice Taylor, Chris Wilcox, Cook, Trent, Okur etc.
Defense/ Rebounder:Ely, Moiso, Cato, Dalambert, Keon Clark, Cook, Diop, Jerome, David West, Tractor, Elson, Birdman etc.
Then you need a player (1,2, or 3) that can come to change tempo or be an energy guy. Something in the lines of a pg that will run the break a lot, and a 2 or 3 that can fill up the score sheet.
eg: Boykins, Jon Barry, Jerome Williams, Desmond, Battier, Rubeun Patterson, Ronald Murray, Madsen, Cardinal, Giricek etc.
If you don't get a really good 3 point shooter after gathering all those players, then you add on of those come in to shoot 3's players, and if you get one with more then thats good
eg: Kyle Korver, Richie Frahm, Pat Garrity, Hoiberg etc.
You would need a third scorer, so one of the other 3 players could fit this role. This applies to all the examples.
With a 1 guard
Same thing, running through the big man, but with the 1 also running the break a lot and doing drive an dish. Again this works if you have a big man that can pass, but with most of the teams they will go to the big man but not run through him.
eg from teams: Parker-Duncan, Francis-Yao, Lebron-Boozer, Kidd-Martin, Gilbert-Kwame (lol), Wade-Odom, Hinrich-Curry-Chandler, Bibby-Webber, Nash-Dirk, Terry-Rahim
At the 2 you need a player that won't wanna score too much, and is a good 3 point shooter and relatively good defender.
eg: Christie, Bowen, Diaw, Stephen Jackson, James Posey, Brent Barry, Ginobili, Battier, Kittles, Morris Peterson (hmm), Kedrick Brown etc.
At the 3, other inside position and bench, the same as when you have a 2 guard.
With a 3
Run through big man, and open the floor for the 3 to be a more effective scorer. Again this works if you have a big man that can pass, but with most of the teams they will go to the big man but not run through him.
eg: Marion-Amare, Lebron-Boozer, Melo-Nene (hmm), Peja-Webber blah blah
At the 2 you get the same kinda player as when you have when its a PG-Big Man.
At the point you get the same as when you have a SG-Big man combo.
The inside and the bench will replicate the two ther options.
From the teams in the league without making many changes:
Jaric
Maggette
James Posey
Brand
Kaman
Bench:
Wilcox
Gary Trent
Jon Barry
Bobby Simmons
other guys
Andre Miller
Carter
Donyell Marshall
Bosh
Dampier
Bench:
Darrell Armstrong
Moiso
Jerome Williams