Srs, the CPU NBA 2k18 defense is completely broken this year. After understanding the mechanics of LeBron James dribbling (which is not even the best in this matter) I simply abuse the CPU defense. Look at this video:
It was 8/8 FG, 100% hit trying for long 5 minutes at SAME PLAY, at the most difficult level of the game (HOF) and increasing the CPU defense sliders.
Try it yourself. Just ask for isolation, put the ball in LeBron's left hand, take the crossover and tighten the turbo.
The game is completely broken for me at this moment.